Mao discusses the assassination of Dr. Martin Luther King Jr. and connects the struggles of Black Americans to the struggles of oppressed people around the world. He calls for people around the world to unite against American imperialism.

Mao argues that Europe remains the strategic center of US-Soviet conflict.

Mao expresses support for an anti-American demonstration that recently occurred in Japan. He calls for Chinese people, Japanese people, and all other oppressed people of the world to unite against the United States.

At the request of Robert F. Williams, a former NAACP leader who fled to Cuba, Mao condemns racism against black Americans in the United States. He discusses several notable events in the American civil rights movement, from the Little Rock Crisis of 1957 to the then-upcoming March on Washington, and calls on "enlightened people of all races around the world" to support the struggle of black Americans.

Mao and Pita Rodríguez discuss various topics such as the need to reform intellectuals and continue the fight against American imperialism in their respective countries. They also discuss the then recent assassination of US President John F. Kennedy on November 22, 1963.